Whereas the Cache API is designed to cache data for a long period or until some condition is met, per-request caching simply means caching the data for the duration of the request. A particular code path is accessed frequently on each request but the data only needs to be fetched, applied, modified, or updated once. This sounds fairly theoretical, so let us consider a concrete example.
In the Forums application of Community Server, each server control used on a page requires personalization data to determine which skin to use, the style sheet to use, as well as other personalization data. Some of this data can be cached for a long period of time, but some data, such as the skin to use for the controls, is fetched once on each request and reused multiple times during the execution of the request.

To accomplish per-request caching, use the ASP.NET HttpContext. An instance of HttpContext is created with every request and is accessible anywhere during that request from the HttpContext.Current property. The HttpContext class has a special Items collection property; objects and data added to this Items collection are cached only for the duration of the request. Just as you can use the Cache to store frequently accessed data, you can use HttpContext.Items to store data that you will use only on a per-request basis. The logic behind this is simple: data is added to the HttpContext.Items collection when it does not exist, and on subsequent lookups the data found in HttpContext.Items is simply returned.